Annual Meeting

2017 Annual Meeting

If you have a proposal or Director nomination that you would like us to include in our Proxy Statement and form of proxy for, or to present at the 2017 Annual Meeting of Stockholders, you must send the proposal to us by no later than December 21, 2016. Stockholders wishing to submit proposals or Director nominations that are not to be included in such Proxy Statement and form of proxy must do so no later than the close of business on February 3, 2017. Stockholders should also review our bylaws, which contain additional requirements with respect to advance notice of stockholder proposals and Director nominations.

2016 Annual Meeting

Ionis Pharmaceuticals, Inc. (the “Company”) held its Annual Meeting of Stockholders on June 3, 2016. The stockholders considered three proposals, each of which is described in more detail in the Company’s definitive proxy statement dated April 15, 2016.

Proposal 1:

Election of directors to hold office until the 2019 Annual Meeting:

FOR

WITHHELD

BROKER
NON-VOTES

Stanley T. Crooke

74,787,512

5,029,186

21,563,698

Joseph Klein, III

78,504,840

1,311,858

21,563,698

Joseph Loscalzo

76,326,735

3,489,963

21,563,698

The Company’s stockholders elected the foregoing candidates, by affirmative votes by a majority of the votes of the shares represented in person or by proxy at the meeting and entitled to vote in the election of directors.

Proposal 2:

Approve an amendment to the Isis Pharmaceuticals, Inc. 2011 Equity Incentive Plan.

"RESOLVED, that Ionis’ stockholders approve, on an advisory basis, the compensation of the named executive officers, as disclosed in this Proxy Statement for the 2016 Annual Meeting of Stockholders pursuant to the compensation disclosure rules of the Securities and Exchange Commission."

FOR

AGAINST

ABSTAIN

BROKER NON-VOTES

77,717,101

1,886,818

212,779

21,563,698

The Company’s stockholders approved the foregoing proposal.

Proposal 3:

Ratify the Audit Committee's selection of Ernst & Young LLP as independent auditors for our 2016 fiscal year:

FOR

AGAINST

ABSTAIN

BROKER NON-VOTES

100,224,042

898,993

257,361

0

The Company’s stockholders approved the foregoing proposal.