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Annual Meeting

2015 Annual Meeting

If you have a proposal or Director nomination that you would like us to include in our Proxy Statement and form of proxy for, or to present at the 2015 Annual Meeting of Stockholders, you must send the proposal to us by no later than December 30, 2014. Stockholders wishing to submit proposals or Director nominations that are not to be included in such Proxy Statement and form of proxy must do so no later than the close of business on February 10, 2015. Stockholders should also review our bylaws, which contain additional requirements with respect to advance notice of stockholder proposals and Director nominations.

2014 Annual Meeting

We are pleased to invite you to Isis Pharmaceuticals, Inc.’s 2014 Annual Meeting of Stockholders. We will host the meeting at our offices in Carlsbad, California on Tuesday, June 10, 2014, at 2:00 p.m. Pacific Time. Following the formal Annual Meeting, we will review the major developments of the past year and our plans for 2014, and answer your questions.

2013 Annual Meeting

Isis Pharmaceuticals, Inc. held its Annual Meeting of Stockholders on June 25, 2013. The stockholders considered four proposals, each of which is described in more detail in the Company’s definitive proxy statement dated April 26, 2013.

Proposal 1: Election of directors to hold office until the 2016 Annual Meeting:

FOR

WITHHELD

Stanley T. Crooke

 

61,349,263

 

4,140,735

Broker Non-Votes: 17,382,531

 

 

FOR

WITHHELD

Joseph Klein, III

 

64,567,175

 

922,823

Broker Non-Votes: 17,382,531

 

 

The foregoing candidates were elected having received affirmative votes by a majority of the votes of the shares represented in person or by proxy at the meeting and entitled to vote in the election of Directors.

Proposal 2: Approve an amendment to the Isis Pharmaceuticals, Inc. 2011 Equity Incentive Plan:

FOR

AGAINST

ABSTAIN

BROKER NON-VOTES

58,213,796

 

7,194,529

 

81,673

 

17,382,531

 

The foregoing proposal was approved.

Proposal 3: Approval, on an advisory basis, of the compensation paid to the Company’s executive officers, including the following resolution:

“RESOLVED, that Isis’ stockholders approve, on an advisory basis, the compensation of the named executive officers, as disclosed in this Proxy Statement for the 2013 Annual Meeting of stockholders pursuant to the compensation disclosure rules of the Securities and Exchange Commission.”

FOR

 

AGAINST

 

ABSTAIN

 

BROKER NON-VOTES

 

63,543,484

 

1,699,614

 

246,900

 

17,382,531

 

The foregoing proposal was approved.

Proposal 4: Ratify the Audit Committee’s selection of Ernst & Young LLP as independent auditors for our 2013 fiscal year:

FOR

 

AGAINST

 

ABSTAIN

 

BROKER NON-VOTES

 

82,244,683

 

326,074

 

301,772

 

0

 

The foregoing proposal was approved.

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